Useful Pharmacokinetic Equations

Useful Pharmacokinetic Equations are mathematical formulas used to describe how drugs are absorbed, distributed, metabolized, and eliminated in the body. They help in understanding the drug's behavior, dosage determination, and predicting drug concentrations in different body compartments over time.

Pharmacokinetic equations are typically filed by pharmaceutical researchers, scientists, and drug development companies.

FAQ

Q: What is the equation for calculating clearance?
A: Clearance = (Dose / AUC)

Q: How is volume of distribution calculated?
A: Volume of distribution = (Dose / Initial plasma concentration)

Q: What is the equation for calculating half-life?
A: Half-life = (0.693 / Clearance)

Q: How can you calculate bioavailability?
A: Bioavailability = (AUC after oral administration / AUC after intravenous administration) x 100

Q: What is the equation for calculating steady-state concentration?
A: Steady-state concentration = (Drug infusion rate / Clearance)

Q: How is elimination rate constant calculated?
A: Elimination rate constant = (0.693 / Half-life)

Q: What is the equation for calculating peak concentration?
A: Peak concentration = (Dose / Volume of distribution)

Q: How can you calculate the area under the concentration-time curve (AUC)?
A: AUC = (C0 / elimination rate constant)

Q: What is the equation for calculating the loading dose?
A: Loading dose = (Target concentration x Volume of distribution) / Bioavailability

Q: How is maintenance dose calculated?
A: Maintenance dose = (Target concentration x Clearance) / Bioavailability